Introduction
The Aspirin Study is exploring the benefits of higher aspirin doses for at-risk pregnant people and their babies to help prevent high blood pressure problems during pregnancy.
The Ohio State University Medical Center, Northwestern Memorial Hospital, and other academic institutions across the U.S. are conducting a multi-year study to find out the benefits of higher aspirin doses for at-risk pregnant people, with funding from PCORI (Patient-Centered Outcomes Research Institute).
Approach
The research team wants to enroll more than 10,000 pregnant people at higher risk for high blood pressure problems during pregnancy at 15 clinical centers across the U.S.
Participants will be randomly assigned to two groups. One group will take 81mg of aspirin daily, and the other group will take 162mg daily. They will be followed until six weeks after delivery. Researchers will compare the two groups based on how often they develop high blood pressure problems, their overall health and birth experience, and whether their baby is born too small or too early, needs special care after delivery, has trouble bonding, or does not survive.
Engagement
This study values the patient's perspective. Therefore, during all steps of the study— including design, enrollment, and completion—we have worked with community members from the sites, The Center for Health Outcomes and Policy Evaluation Studies (HOPES) at The Ohio State University, national stakeholders, and The Preeclampsia Foundation.
